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Lungs from newborn MMP-2−/− mice phenocopy branching defects in Egfr−/− mice. HandE stained sections from lungs of newborn (a) MMP-2−/−, (c) Egfr−/−, (b,d) their wild type littermate controls, respectively. Note that the distal airway phenotype of MMP-2−/− mice resembles that of the Egfr−/− mice. Bar, 200 μm (a–d).
