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. Author manuscript; available in PMC: 2009 Dec 4.
Published in final edited form as: Leuk Lymphoma. 2008;49(Suppl 1):27–34. doi: 10.1080/10428190802311417

Figure 1. Generation of EBV-specific cytotoxic T cells.

Figure 1

Peripheral blood mononuclear cells (PBMCs) from donor blood are infected with a laboratory strain of EBV to set up a B-cell lymphoblastoid cell line (LCL). These cells show the same pattern of EBV gene expression as those derived from type III latency EBV malignancies such as post-transplant lymphoproliferative disease (PTLD). Irradiated LCLs are then used to stimulate another aliquot of PBMCs resulting in expanded EBV-specific cytotoxic T cells (CTLs).