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. Author manuscript; available in PMC: 2010 Sep 1.
Published in final edited form as: Gastroenterology. 2009 Jun 6;137(3):1072–1082.e6. doi: 10.1053/j.gastro.2009.05.052

Figure 3. High levels of Ras activity in pancreatic acinar cells led to the development of CP.

Figure 3

(A) At 5 days after birth, pancreata from cLGL-KRas/Ela-CreERT mice showed normal histology except for occasional sites of ADM. (B) At 9 days after birth, acinar cells were depleted from many areas with the development of fibrotic stroma. (C) In adult mice (2 months), the fibrosis expanded with abundant intercellular collagen deposition. (D) The stromal compartment of the pancreas (2 weeks old) showed abundant SMA expression.