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. Author manuscript; available in PMC: 2010 Sep 1.
Published in final edited form as: Gastroenterology. 2009 Jun 6;137(3):1072–1082.e6. doi: 10.1053/j.gastro.2009.05.052

Figure 4. Elevated Ras activity in pancreatic acinar cells caused acinar cell senescence and stellate cell activation.

Figure 4

(A) In adult cLGL-KRas/Ela-CreERT mice (2 months old) many acinar cells stained positive for senescence-associated β-galactosidase. (B) Few pancreatic acinar cells showed apoptosis (arrow) as indicated by TUNEL assay (2 months old). DNase-treated tissue served as a positive control (insert). (C) DEC1 and p53 was up-regulated in cLGL-KRas/Ela-CreERT (cLGL/Cre) mice (2 months old) as measured by Western blot. D. Quantative RT-PCR showed that p15, p16, IL-1B, IL-6, Gro-α and GM-CSF were upregulated (shown in log2 scale) in cLGL-KRas/Ela-CreERT mice (1 month old) as compared with wild type littermate controls.