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. Author manuscript; available in PMC: 2010 Sep 1.
Published in final edited form as: Gastroenterology. 2009 Jun 6;137(3):1072–1082.e6. doi: 10.1053/j.gastro.2009.05.052

Figure 5. High levels of Ras activity caused acinar-to-ductal metaplasia and led to the formation of mPanINs and cystic papillary carcinoma.

Figure 5

(A) In cLGL-KRas/Ela-CreERT mice (2 months old) acinar-to-ductal metaplasia (arrows) were observed. (B–E) Transgenic expression of mutant K-Ras induced typical mPanINs which progressed over time including mPanIN-1 (B, 2 months), mPanIN-2 (C, 4 months), and mPanIN-3 (D, 6 months) lesions and cystic papillary carcinoma (E, 7 months). (F) The grade of the mPanIN lesions present in the pancreas of transgenic animals progressed with age. Each group consisted of ~20 animals.