Table 3.
Relationship between variables and the EQ-5D index - pooled effect and heterogeneity from evidence synthesis across studies
| Variable | Pooled effect (95% CI) | Heterogeneity as measured by I2, p-value |
|---|---|---|
| Age (10 year increment) | 0.02 (-0.01, 0.04) | 61%, < 0.001 |
| Sex (Men vs. women) | 0.09 (0.04, 0.14) | 93%, <0.001 |
| ETT (1 minute increment) | 0.019 (0.014, 0.025) | 36%, 0.10 |
| CCS (1 class increase) | 0.11 (0.09, 0.13) | 86%, <0.001 |
| SAQ - ECS (10 unit increment) | 0.066 (0.053, 0.079) | 87%, <0.001 |
| SAQ - ASS (10 unit increment) | 0.039 (0.029, 0.049) | 51%, 0.02 |
| SAQ - AFS (10 unit increment) | 0.052 (0.039, 0.067) | 87%, <0.001 |
| SAQ - TSS (10 unit increment) | 0.044 (0.032, 0.056) | 0, 0.45 |
| SAQ - DPS (10 unit increment) | 0.063 (0.047, 0.079) | 87%, <0.001 |
| SF-6D (0.10 unit increment) | 0.17 (0.16, 0.19) | 83%, <0.001 |
Key: EQ-5D - EuroQol 5D, I2 - I2 index for quantifying heterogeneity, ETT - Treadmill exercise test, CCS - Canadian Cardiovascular Society angina classification, SAQ - Seattle Angina Questionnaire, ECS - exertional capacity scale, ASS - angina severity scale, AFS - anginal frequency scale, TSS - treatment satisfaction scale, DPS - disease perception scale, SF-6D - short form 6D