Table 4.
Results of repeated measures ANOVA about the changes of mean TGF-β1 level during the course of radiation therapy
| Mean ± SD (× 104 pg/ml) | Repeated measures ANOVA | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Before RT | Beginning of RT | Middle of RT | End of RT | 2 wks after RT | 4 wks after RT | Source | F | p value | |
| RP1 (n = 17) |
2.8 ± 0.8 | 2.4 ± 0.7 | 2.0 ± 0.6 | 2.1 ± 0.7 | 2.1 ± 0.4 | 2.8 ± 1.1 | RP1 | 0.28 | 0.598 |
| Non-RP (n = 17) |
2.3 ± 1.1 | 2.5 ± 1.1 | 2.4 ± 1.2 | 2.2 ± 0.9 | 2.0 ± 0.8 | 1.7 ± 0.5 | time | 2.36 | 0.043 |
| time*RP1 | 4.79 | 0.001 | |||||||
| RP2 (n = 8) |
2.5 ± 1.0 | 1.9 ± 0.6 | 1.8 ± 0.7 | 1.9 ± 0.6 | 2.1 ± 0.7 | 3.3 ± 1.7 | RP2 | 0.05 | 0.828 |
| Non-RP | 2.6 ± 0.9 | 2.6 ± 0.9 | 2.3 ± 0.9 | 2.2 ± 0.8 | 2.0 ± 0.9 | 2.0 ± 0.9 | time | 3.24 | 0.008 |
| (n = 26) | time*RP2 | 6.27 | 0.0001 | ||||||
Abbreviations: RT, radiation therapy; wks, weeks; RP1, development of any grade of radiation pneumonitis; RP2, development of grade ≥ 2 radiation pneumonitis