Table 1.

Hormone levels (mean ± SEM) in intact wild-type, Kiss1^−/−, and Gpr54^−/− mice treated with acyline or vehicle (PBS). P values are for differences between acyline and vehicle treatment. The lower end of the measurable range was 2.6 ng/mL for FSH, 0.04 ng/mL for LH, and 6.2 ng/dL for testosterone.

female	wild-type			Kiss1−/−			Gpr54−/−
	vehicle	acyline	P	vehicle	acyline	P	vehicle	acyline	P
FSH (ng/mL)	5.7 ± 2.6 (n=7)	2.7 ± 0.1 (n=4)	0.18	3.4 ± 0.2 (n=8)	2.6 ± 0 * (n=8)	0.007	3.4 ± 0.1 (n=3)	2.9 ± 0.5 (n=4)	0.53
LH (ng/mL)	0.62 ± 0.25 (n=7)	0.07 ± 0.02 (n=4)	0.07	0.61 ± 0.17 (n=10)	0.05 ± 0.01 (n=9)	0.01	0.96 ± 0.06 (n=3)	0.04 ± 0 * (n=4)	0.26
male
FSH (ng/mL)	12.6 +/− 2.2 (n=8)	2.6 ± 0 * (n=8)	0.002	2.6 ± 0 * (n=7)	2.6 ± 0 * (n=6)	ND	2.6 ± 0 * (n=7)	2.6 ± 0 * (n=5)	ND
LH (ng/mL)	0.78 ± 0.46 (n=8)	0.04 ± 0 * (n=8)	0.15	0.73 ± 0.58 (n=7)	0.04 ± 0 * (n=6)	0.28	0.34 ± 0.14 (n=7)	0.04 ± 0 * (n=5)	0.07
testosterone (ng/dL)	90.4 ± 51.0 (n=7)	11.1 ± 2.6 (n=8)	0.17	79.0 ± 36.2 (n=7)	10.4 ± 2.6 (n=6)	0.11	22.1 ± 2.6 (n=7)	33.3 ± 12.4 (n=5)	0.42

Asterisks, all measurements were below the reportable range; ND, not determinable.