Mean immunoreactivity scores±SEM for NOS isoforms in choroidal structures of aged control (black) and AMD (white) eyes. The immunoreactivity scores for eNOS were significantly lower in choroidal arteries, cells in stroma, and leukocytes in blood vessel lumens in AMD choroid. nNOS was significantly lower in RPE nuclei, arteries and veins as well as leukocytes. There was no significant difference in iNOS levels between aged control and AMD choroids except in leukocytes. The significance of the difference between the groups by t test is indicated: *= p<0.01, **= p<0.005, ***= p<0.001.