Skip to main content
. Author manuscript; available in PMC: 2011 Jan 1.
Published in final edited form as: Exp Eye Res. 2009 Oct 15;90(1):155–167. doi: 10.1016/j.exer.2009.10.004

Figure 5.

Figure 5

Immunoreactivity for NOS isoforms in AMD eye with geographic atrophy (subject 15). Note that the non-atrophic area (A) of choroid has RPE (arrowhead) and there is PAS-positive thickened Bruch's membrane (open arrowhead) but there is no RPE in atrophic area (B). CD34 demonstrates CC (arrows) is limited in the atrophic area compared to the non-atrophic area (C, D). In non-atrophic area, eNOS (E) is prominent in CC and endothelial cells of large blood vessels (asterisks) as well as cells in stroma, which may include melanocytes. nNOS (G) is prominent in RPE nuclei (at high magnification, Inset) and perivascular nerve fibers (double arrows). iNOS (I) appears similar to nNOS. The similarity with nNOS may be due to cross reactivity of the antibodies. Immunoreactivity for NOS isoforms is greatly reduced in choroid structures in the atrophic area (F, H, J). Magnification bar (A–J) = 30 μm.