Fig. 3.

MLN DCs following 7 days of Nippostrongylus brasiliensis infection. (A) Expansion of lymph node cell numbers during infection; left panel shows total CD11c⁺ numbers in MLNs from naïve mice and from mice taken 7 days following N. brasiliensis infection. Right panel shows percentage of CD11c⁺ cells within total MLN populations in each group of mice. (B) CD11c⁺ DCs following N. brasiliensis infection (grey fill) show diminished CD40 and CD86 expression, but unaltered CD80 or MHC class II expression. (C) Differences in geometric mean fluorescence intensity for CD40 and CD86 staining between MLN CD11c⁺ DCs from naïve mice and from mice taken 7 days following N. brasiliensis infection. (D) Frequency of CD8^intCD86^hi cells is reduced following N. brasiliensis infection. (E) Within the CD8 subpopulations, N. brasiliensis infection (grey fill), has a differential effect on peak CD40 expression.