. Author manuscript; available in PMC: 2009 Dec 5.

Published in final edited form as: CNS Spectr. 2007 Mar;12(3):211–220. doi: 10.1017/s1092852900020939

TABLE 3.

The Effect of eCB Modulators on the Extinction of Conditioned Fear

Authors (Year)	Manipulation/Drug Type	Drug Name	Behavioral Paradigm	Measure of Fear	Observation
Marsicano et al (2002)⁶⁴	CB1 gene knockout	N/A	Extinction of conditioned fear (cue)	Conditioned freezing	Impairment of extinction
Chhatwal et al (2005)⁶⁶	CB1 agonist	WIN 55,212-2	Extinction of conditioned fear (cue)	Fear-potentiated startle	No effect
Suzuki et al (2004)⁷⁶	CB1 antagonist	Rimonabant	Extinction of conditioned fear (context)	Conditioned freezing	Impairment of extinction
Marsicano et al (2002)⁶⁴	CB1 antagonist	Rimonabant	Extinction of conditioned fear (cue)	Conditioned freezing	Impairment of extinction
Chhatwal et al (2005)⁶⁶	CB1 antagonist	Rimonabant	Extinction of conditioned fear (cue)	Fear-potentiated startle	Impairment of extinction
Chhatwal et al (2005)⁶⁶	FAAH inhibitor, eCB reuptake inhibitor	AM404	Extinction of conditioned fear (cue)	Fear-potentiated startle	Enhancement of extinction

eCB=endogenous cannabinoid; CB1=cannabinoid-type 1; N/A=not applicable; FAAH=fatty acid amide hydrolase.

Chhatwal JP, Ressler KJ.