Fig. 2.

Neurite outgrowth is stimulated from cortex and DRG explants obtained from lesioned animals treated with CD2019. Animals were treated at the time of lesion by i.c.v. with 180 ng/kg CD2019/day for 14 days. Neurite outgrowth from explants of (A) cortex from lesion animals plus vehicle, (B) cortex from lesion animals treated with CD2019, (C) DRG from the region of the lesion treated with vehicle, (D) DRG from the region of the lesion treated with CD2019, (E) quantification of neurite outgrowth. There are significantly more neuritis, and their lengths are longer from explants of both cortex and DRG obtained from lesioned animals treated with CD2019 compared to vehicle-treated ones. Error bars show SEM, asterisks denote significant difference between vehicle and CD2019 treatment. ⁎P < 0.005, Student's t-test, n = 3 explants from three different animals. Scale bar: 100 μm.