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. Author manuscript; available in PMC: 2010 Oct 1.
Published in final edited form as: Exerc Sport Sci Rev. 2009 Oct;37(4):188–195. doi: 10.1097/JES.0b013e3181b7b7c5

Figure 2.

Figure 2

Schematic diagrams depict some key elements of two human Rab GTPase activating proteins (GAP): Akt substrate of 160 kDa (AS160 or TBC1D4) and TBC1D1 (7, 13, 23–25, 30). Each protein includes two phosphotyrosine binding (PTB) domains, a calmodulin binding domain (CBD) and a GAP domain. AS160 includes more Akt phosphomotifs than TBC1D1. TBC1D1 includes an adenosine monophosphate (AMP)-activated protein kinase (AMPK) phosphomotif between the PTB domains that is absent from AS160. For clarity, the list of phosphomotifs identified in the figure is incomplete. TBC1D indicates tre-2/USP6, BUB2, cdc16 domain.