Table 3.
Risk factors associated with high-risk (HR) human papillomavirus (HPV) acquisition among initially HPV negative women
| Acquistion of one HR HPV type |
Acquistion of multiple HR HPV types |
|||||
|---|---|---|---|---|---|---|
| Number of cases# | OR## | 95% CI | Number of cases# | OR## | 95% CI | |
| Age (years) | ||||||
| 27–29 | 118 | 1.00 | ref. | 79 | 1.00 | ref. |
| 24–26 | 131 | 1.25 | 0.96–1.63 | 119 | 1.61 | 1.19–2.18 |
| 20–23 | 150 | 1.50 | 1.15–1.97 | 201 | 2.48 | 1.85–3.32 |
| per year (linear) | 1.06 | 1.02–1.11 | 1.14 | 1.10–1.19 | ||
| Number of sexual partners during follow-up | ||||||
| Married/cohabiting: | ||||||
| 0–1 | 100 | 1.00 | ref. | 40 | 1.00 | ref. |
| 2–3 | 40 | 2.29 | 1.56–3.35 | 41 | 5.69 | 3.63–8.91 |
| ≥ 4 | 19 | 4.15 | 2.45–7.02 | 32 | 15.39 | 9.26–25.58 |
| per partner (linear) | 1.25 | 1.15–1.36 | 1.47 | 1.33–1.62 | ||
| Single: | ||||||
| 0–1 | 76 | 1.00 | ref. | 58 | 1.00 | ref. |
| 2–3 | 97 | 1.51 | 1.10–2.08 | 120 | 2.63 | 1.89–3.66 |
| ≥ 4 | 66 | 1.80 | 1.27–2.55 | 106 | 4.01 | 2.84–5.65 |
| per partner (linear) | 1.05 | 1.02–1.09 | 1.12 | 1.07–1.16 | ||
| Self-reported history of genital Chlamydia infection | ||||||
| No | 337 | 1.00 | ref. | 347 | 1.00 | ref. |
| Yes | 62 | 0.95 | 0.71–1.27 | 52 | 0.76 | 0.55–1.04 |
| Self-reported history of genital warts | ||||||
| No | 340 | 1.00 | ref. | 343 | 1.00 | ref. |
| Yes | 59 | 0.94 | 0.70–1.26 | 56 | 0.94 | 0.69–1.28 |
| Parity | ||||||
| Nulliparous | 342 | 1.00 | ref. | 375 | 1.00 | ref. |
| Parous | 57 | 1.02 | 0.75–1.40 | 24 | 0.57 | 0.37–0.90 |
| Use of oral contraceptives (years) | ||||||
| Noncurrent use | 263 | 1.00 | ref. | 230 | 1.00 | ref. |
| Current use: | ||||||
| ≤2 | 22 | 0.63 | 0.39–1.01 | 35 | 1.01 | 0.68–1.50 |
| 3–4 | 38 | 1.12 | 0.77–1.62 | 47 | 1.39 | 0.98–1.99 |
| 5–6 | 30 | 0.93 | 0.63–1.39 | 40 | 1.44 | 1.00–2.07 |
| ≥7 | 46 | 1.24 | 0.89–1.73 | 47 | 1.66 | 1.17–2.35 |
| per year (linear) | 1.07 | 1.01–1.14 | 1.04 | 0.98–1.10 | ||
| Condom use | ||||||
| Noncurrent use | 216 | 1.00 | ref. | 189 | 1.00 | ref. |
| Current use | 183 | 0.92 | 0.73–1.16 | 210 | 1.26 | 0.99–1.62 |
| Amount of smoking (cigarettes/day) | ||||||
| Noncurrent smokers | 189 | 1.00 | ref. | 214 | 1.00 | ref. |
| Current smokers: | ||||||
| 1–9 | 45 | 1.16 | 0.83–1.63 | 49 | 1.04 | 0.75–1.46 |
| ≥ 10 | 165 | 1.52 | 1.22–1.90 | 136 | 1.04 | 0.82–1.32 |
#
The sum will not always add up to the total because of missing values
##
Adjusted for age (linear), no. of sexual partners during follow-up (linear), marital status (single/married), use of oral contraceptives (current/noncurrent and years of use among current users(linear)), and interaction between marital status and no. of sexual partners during follow-up