Figure 1. The psychostimulant amphetamine enhanced PKC activity in both membrane fraction and cytosol fraction of forebrain in vivo.
Mice were treated with amphetamine (AMPH, 5mg/kg, i.p.) for 10 days. Prefrontal cortex (Fcx) was dissected and fractionated into membranous and cytosolic fractions. PKC activity was determined with neurogranin (Ng) peptide as a substrate. (Student’s t-test, * p<0.05, N=5-8).