Figure 8. AMPA GluA1T840 and GluAS831 phosphorylation regulated by PKC in mania-associated animal models.
Total protein samples from the prefrontal cortex of sleep deprived animals or amphetamine (AMPH)-, imipramine (IMI)-, or lithium (Li)-treated animals were subjected to Western blot analysis with anti-phospho-GluA1T840, anti-phospho-GluA1S831, or anti-GluA1 antibodies. Data are presented as mean±SE (*p<0.05 Student’s t-test. N=8 animals for each group).
(A) Phospho-GluA1T840 levels in mania-related animal models.
(B) Phospho-GluA1S831 levels in mania related animal models
(C) Total GluA1 levels in mania related animal models.