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. 2009 Dec 14;4(12):e8283. doi: 10.1371/journal.pone.0008283

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Srinivasan et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Representative micrographs of phalloidin stained control (top) and DKO (bottom) aortic EC (n = 3). Red = Actin and Green = lentivirus infected cells. The bar graph represents % EC showing the presence of intra-cellular stress fibers. Bars = 20 µm. (B) Representative micrographs of Paxillin-pFAK membrane co-localization on FN-coated dishes in Erk1^−/−;Erk2^fl/fl (top) and Erk1^−/−;Erk2^fl/fl+Cre (bottom) aortic EC (n = 3). Red-Paxillin and Green-pY397 FAK. Boxed areas are enlarged to show membrane staining in EC. Graphic panel represents % EC showing Paxillin-pY397 FAK co-localization. Bars = 20 µm. (C) Western blot with indicated antibodies of lentivirus infected aortic EC. Erk1^+/−;Erk2^fl/fl (lane 1) and Erk1^−/−;Erk2^fl/fl without (lane 2) and with (lane 3) Cre.