Table 2.

Univariate and Multivariate Associations of B7-H1, Survivin, and Ki-67 Expression With RCC-specific Death for 634 Patients With ccRCC

Biomarker	Univariate		Multivariate*
	HR (95% CI)	P	HR (95% CI)	P
Survivin and Ki-67 as continuous
B7-H1
Negative	1.0 (reference)		1.0 (reference)
Positive	3.98 (2.96–5.33)	<.001	1.97 (1.41–2.75)	<.001
Survivin, 5-unit increase	1.17 (1.15–1.20)	<.001	1.11 (1.08–1.14)	<.001
Ki-67, 5-unit increase	1.04 (1.03–1.05)	<.001	1.02 (1.02–1.03)	<.001
Survivin and Ki-67 as quartiles
B7-H1
Negative	1.0 (reference)		1.0 (reference)
Positive	3.98 (2.96–5.33)	<.001	2.14 (1.54–2.96)	<.001
Survivin
1st quartile, 0–2.9	1.0 (reference)		1.0 (reference)
2nd quartile, 3.0–7.9	1.40 (0.84–2.33)	.193	1.19 (0.71–1.99)	.517
3rd quartile, 8.0–19.9	1.92 (1.16–3.18)	.011	1.28 (0.75–2.20)	.360
4th quartile, ≥20	6.74 (4.28–10.64)	<.001	2.85 (1.66–4.87)	<.001
Ki-67
1st quartile, 0–14.9	1.0 (reference)		1.0 (reference)
2nd quartile, 15.0–34.9	1.62 (0.94–2.78)	.080	1.50 (0.86–2.62)	.152
3rd quartile, 35.0–74.9	2.34 (1.41–3.90)	.001	1.81 (1.06–3.09)	.031
4th quartile, ≥75	6.36 (3.98–10.19)	<.001	3.17 (1.85–5.43)	<.001
Survivin and Ki-67 as dichotomous
B7-H1
Negative	1.0 (reference)		1.0 (reference)
Positive	3.98 (2.96–5.33)	<.001	2.16 (1.57–2.96)	<.001
Survivin
Low, <15	1.0 (reference)		1.0 (reference)
High, ≥15	4.56 (3.46–6.00)	<.001	2.76 (2.00–3.80)	<.001
Ki-67
Low, <50	1.0 (reference)		1.0 (reference)
High, ≥50	3.42 (2.59–4.52)	<.001	1.95 (1.42–2.67)	<.001

RCC indicates renal cell carcinoma; ccRCC, clear cell renal cell carcinoma; HR, hazard ratio; CI, confidence interval.

^*Multivariate HRs for each biomarker were adjusted for the effects of the remaining 2.