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. 2009 Sep 23;29(38):11794–11806. doi: 10.1523/JNEUROSCI.0888-09.2009

Figure 4.

Figure 4.

Fyn is dysregulated in dy/dy brains. A, Lysates from 3-week-old cerebral cortices (CTX) were evaluated by Western blot to detect Fyn, phosphorylated tyrosine 529 (pY529), Csk, Cbp, and actin. Representative blots from 3-week-old wild-type (wt) and dy/dy (dy) littermates are shown. B, Densitometric analysis of Fyn, phospho-Fyn, and Fyn regulatory proteins Csk and Cbp: mean Fyn protein, mean phospho-Y529 immunoreactivity normalized to total Fyn protein, mean Csk protein, and mean Cbp protein are shown (n = 3; **p < 0.01; *p < 0.05). Fyn, Csk, and Cbp protein levels were normalized to actin protein levels. C, Lysates from 3-week-old cerebella (CB) were evaluated by Western blot to detect Fyn, phosphorylated tyrosine 529 (pY529), Csk, Cbp, and actin. Representative blots from 3-week-old wild-type and dy/dy littermates are shown. D, Densitometric analysis of Fyn, phospho-Fyn, and Fyn regulatory proteins Csk and Cbp: mean Fyn protein, mean phospho-Y529 immunoreactivity normalized to total Fyn protein, mean Csk protein, and mean Cbp protein are shown (n = 3; *p < 0.05). Fyn, Csk, and Cbp protein levels were normalized to actin protein levels.