Table 1.
List of Knockout/Transgenic Mice Studied
| Gene | Description of Genetic Manipulation | Abbreviation | Reference |
|---|---|---|---|
| Knockout Mice | |||
| Mn-Superoxide Dismutase | Deletion of exon 3 of Sod2 gene | Sod2+/- | [21] |
| Cu/Zn-Superoxide Dismutase | Deletion of exon 3 and 4 of Sod1 gene | Sod1-/- | [32] |
| Glutathione Peroxidase 1 | Deletion of exon 2 of Gpx1 gene | Gpx1-/- | [35] |
| Glutathione Peroxidase 4 | Deletion of exon 3, 4, 5, 6, and 7 of Gpx4 gene | Gpx4+/- | [16] |
| Methionine Sulfoxide Reductase A | Deletion of exon 2 on MsrA gene | MsrA+/- | [45] |
| Thioredoxin 2 | Mutational insertion in exon 1 of Trx2 gene | Trx2+/- | [48] |
| Transgenic Mice | |||
| Cu/Zn-Superoxide Dismutase | 64 Kb genomic fragment of the human SOD1 gene containing 27 Kb of 5' and 3'-flanking sequences. | SOD1 Tg | [53] |
| Mn-Superoxide Dismutase | 13Kb of the genomic fragment of Sod2 mouse gene. | Sod2 Tg | [55] |
| Catalase | 80Kb genomic fragment of human catalase gene containing 41 Kb of 5' and 6Kb of the 3'flanking sequences. | CAT Tg | [53] |
| Glutathione Peroxidase 4 | 53Kb genomic fragment of human Gpx4 gene containing 30Kb of 5' and 20Kb of 3' flanking sequences. | GPX4 Tg | [58] |
The descriptions of the genetic manipulation for each animal model described in Table 1 were taken from the references given.