Table 2.
Survival Data for Mice Deficient in Antioxidant Enzymes
| Genotype | Strain | Sex | N | Survival Curve (p=) | Mean | Median | 90% | Maximum | Reference |
|---|---|---|---|---|---|---|---|---|---|
| WT | C57BL/6 | Female | 66 | 894 ± 19 | 913 (855-943) | 1034 (1002-1009) | 1189 | [17] | |
| Sod2+/- | C57BL/6 | Female | 68 | 0.12 | 918 ± 19 | 940 (900-959) | 1088 (1044-1196) | 1239 | [17] |
| WT | C57BL/6 | Female | 50 | 915 ± 27 | 963 (923-996) | 1145 (1071-1220) | 1220 | [16] | |
| Gpx4+/- | C57BL/6 | Female | 50 | 0.32 | 964 ± 23 | 1029 (979-1050)* | 1026 (1085-1157) | 1157 | [16] |
| WT | C57BL/6 | Mixed | 68 | 891 ± 24 | 926 (874-994) | 1091 (1040-1188) | 1298 | [38] | |
| Gpx1-/- | C57BL/6 | Mixed | 59 | 0.70 | 903 ± 19 | 908 (853-963) | 1063 (1031-1183) | 1226 | [38] |
| Sod2+/- X Gpx1+/- | C57BL/6 | Mixed | 25 | 0.61 | 880 ± 33 | 877 (791-943) | 1057 (1027-1298) | 1283 | [38] |
| Sod2+/- X Gpx1-/- | C57BL/6 | Mixed | 33 | 0.76 | 905 ± 25 | 911 (833-983) | 1121 (1069-1248) | 1248 | [38] |
| Controla | Mixedb | Male | 37 | 925 ± 32 | 926 (868-1030) | 1120 (1092-1204) | 1204 | [46] | |
| MsrA-/- | Mixedb | Male | 25 | 0.87 | 942 ± 34 | 959 (858-1056) | 1156 (1122-1203) | 1203 | [46] |
| WT | C57BL/6 | Mixed | 50 | 902 ± 23 | 921 (874-993) | 1076 (1035-1298) | 1298 | UP | |
| Sod1-/- | C57BL/6 | Mixed | 10 | < 0.001 | 693 ± 41* | 755 (638-761) | 762 (761-767) | 767 | UP |
| Gpx1-/-XSod1-/- | C57BL/6 | Male | 11 | 0.004 | 725 ± 48 | 773*(674-823) | 828 (799-868) | 868 | UP |
| Gpx4+/-XSod1-/- | C57BL/6 | Male | 16 | 0.004 | 667 ± 42* | 672*(563-817) | 866 (817-883) | 883 | UP |
| Sod1-/-XSod2+/- | C57BL/6 | Mixed | 11 | < 0.001 | 730 ± 53 | 778 (674-823) | 886 (817-883) | 908 | UP |
| Gpx4+/-XGpx1-/- | C57BL/6 | Mixed | 40 | 0.85 | 933 ± 25 | 917 (866-1013) | 1124 (1086-1248) | 1248 | UP |
| Gpx4+/-XSod2+/- | C57BL/6 | Mixed | 11 | 0.85 | 906 ± 33 | 918 (824-1017) | 1025 (938-1099) | 1099 | UP |
| WT | Mixedb | Female | 16 | 913 ± 56 | 879 (802-1074) | 1186 (1086-1359) | 1359 | UP | |
| Trx2+/- | Mixedb | Female | 26 | 0.23 | 846 ± 36 | 855 (781-959) | 1059 (1020-1139) | 1139 | UP |
The survival data were taken from references given (UP = unpublished) and are presented together in the groups of mice in which the survival experiments were conducted. The survival data are expressed in days as mean ± SEM, median and 90% (when 90% of the mice have died) with 95% confidence interval in parenthesis, and maximum (age when the oldest mouse in the cohort died). The survival curves for the WT and knockout mice were statistically analyzed by the log-rank test, and the p values are given under survival curve column.
Control mice contained both MsrA+/+ and MsrA+/- mice.
The genetic background is a mixture of C57BL/6 and 129
Values significantly different from the WT mice at the p < 0.05 level.