FIG. 2.

Molecular transport machinery involved in mitochondrial transport. Kinesins and dynein/dynactin complex are responsible for the anterograde and retrograde transport of mitochondria, respectively. Kinesins bind to mitochondria through specific adaptors, and dynein, through dynactin. Syntaphilin docks mitochondria to the microtubules and immobilizes them. The polarity of the microtubule (plus and minus end) is indicated. Myosin, which binds to actin filaments, also can interact with mitochondria and modulate transport.