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. Author manuscript; available in PMC: 2009 Dec 7.
Published in final edited form as: Psychol Bull. 2009 Sep;135(5):707–730. doi: 10.1037/a0016441

Table 2.

General Psychosocial Processes as Mediators of the Association between Sexual Orientation and/or Stigma-related Stress and Psychopathology

Between-Group Studies of LGB and Heterosexuals
Citation Design/Sample Stressor/Status Mediator(s) Outcome Results consistent with mediation?
Coping/Emotion Regulation
Hatzenbuehler, McLaughlin, & Nolen-Hoeksema, 2008 Longitudinal; 29 LGB and 1235 heterosexual adolescents (grades 6–8); representative, community-based sample Sexual Minority Status (same-sex attraction) Emotion dysregulation (rumination and emotional awareness) Depressive and anxiety symptoms Yes
Hatzenbuehler, Corbin, & Fromme, 2008b Cross-sectional; 111 LGB and 2275 heterosexual young adults; representative, community-based sample Stressor (Discrimination) Coping motives Alcohol-related problems Yes
Matthews et al., 2002 Cross-sectional; 583 lesbians and bisexuals, 270 heterosexual women; community-based sample from 3 urban cities Sexual minority status (sexual attraction and behavior) Coping (e.g., suppression, distraction), emotionality Suicidality and depressive distress (treatment for depression) No
Safren & Heimberg, 1999 Cross-sectional; 56 LGB and 48 heterosexual youth; convenience sample Sexual minority status (self-identification as LGB) Acceptance coping (e.g., reappraisal) Depressive symptoms, suicidality Partial mediation for suicide; full mediation for depression
Social/interpersonal
Eisenberg & Resnick, 2006 Cross-sectional; 2,255 sexual minority and 19672 heterosexual adolescents; representative sample of Minnesota youth Sexual minority status (sexual behavior) Family connectedness, teacher & adult caring, school safety Suicidality Yes
Eisenberg & Wechsler, 2003 Cross-sectional; 630 LGB college students; national random sample Sexual minority status (self-identification as LGB) Social norms, social support (campus LGB resources) Alcohol use (binge drinking); tobacco use Reduction in association between LGB status and substance use not tested.
Hatzenbuehler, Corbin, & Fromme, 2008a Longitudinal; 111 LGB and 2109 heterosexual young adults; representative, community-based sample Sexual minoritystatus (self-identification as LGB and sexual behavior) Social norms Alcohol use Yes
Plöderl & Fartacek, 2005 Cross-sectional; 358 LGB and 267 matched heterosexual comparison; convenience sample Sexual minority Status (attraction, behavior and identification) Social support (from family) Suicidality Yes
Safren & Heimberg, 1999 Cross-sectional; 56 LGB and 48 heterosexual youth; convenience sample Sexual minority status (self-identification as LGB) Social support Depressive symptoms, suicidality Partial mediation for suicide; full mediation for depression
Wichstrom & Hegna, 2003 Longitudinal; 190 sexual minority and 2,734 heterosexual adolescents; nationally representative study Sexual minority status (sexual behavior) Social support Suicide attempts No
Cognitive
Austin et al., 2004 Cross-sectional; 511 LGB and 9296 heterosexual adolescents; community-based population of adolescents living throughout U.S. Sexual minority status (feelings of attraction) Self-esteem Tobacco use and dependence. No.
Hatzenbuehler, Corbin, & Fromme, 2008b Cross-sectional; 111 LGB and 2275 heterosexual young adults; representative, community-based sample Stressor (Discrimination) Positive alcohol expectancies Alcohol-related problems Yes
Plöderl & Fartacek, 2005 Cross-sectional; 358 LGB and 267 matched heterosexual comparison; convenience sample Sexual minority status (attraction, behavior and identification) Hopelessness, self-esteem Suicidality Yes
Russell & Joyner, 2001 Cross-sectional; 867 sexual minority and 11,073 heterosexual youth (grades 7–12); nationally representative survey (Add Health Study) Sexual minority status (same-sex attraction) Hopelessness Suicide Partial reduction in association between sexual minority status and suicidal thoughts and behaviors
Safren & Heimberg, 1999 Cross-sectional; 56 LGB and 48 heterosexual youth; convenience sample Sexual minority status (self-identification as LGB) Hopelessness Depressive symptoms, suicidality Partial mediation for suicide; full mediation for depression
Wichstrom & Hegna, 2003 Longitudinal; 190 sexual minority and 2,734 heterosexual adolescents; nationally representative study Sexual minority status (sexual behavior) Global self-worth Suicide attempts No
Ziyadeh et al., 2007 Cross-sectional; 100 LGB adolescents; 9,631 heterosexual and “mostly heterosexual”; nationally representative study Sexual minority status (attraction and identification) Positive alcohol expectancies, self-esteem Alcohol use behaviors Partial (for girls, but not boys); results not consistent for all alcohol outcomes
Within-Group Studies of LGB individuals
Citation Design/Sample Stressor Mediator(s) Outcome Results consistent with mediation?
Diaz, Ayala, Bein, Henne, & Marin, 2001 Cross-sectional; 912 adult Latino gay men; probability sample from 3 cities Discrimination Social isolation Psychological distress (depression and anxiety) Yes
Hatzenbuehler, Nolen-Hoeksema, & Dovidio, in press Longitudinal (experience sampling study); 31 LGB young adults; convenience sample Stigma-related stress (discrimination, rejection sensitivity, felt stigma) Rumination, suppression, social isolation Psychological distress Support for rumination and social isolation; Suppression occurred more on days when stigma stressors were reported, but did not mediate the stigma-distress association
Hatzenbuehler, Hilt, & Nolen-Hoeksema, in press Longitudinal; 74 bereaved gay men; convenience sample Perceived danger Rumination, social support, pessimism Depressive and anxiety symptoms Yes
Hershberger & D’Augelli, 1995 Cross-sectional; 165 LGB young adults (aged 15–21); convenience sample Victimization Family support, self-acceptance (self esteem and comfort with gay identity) Psychological distress and suicidality Partial (support for psychological distress but not for suicidality)
Rosario, Rotheram-Borus, & Reid, 1996 Cross-sectional; 136 gay and bisexual male youths; convenience sample Gay-related stress Self-esteem Emotional distress; problem behaviors No
Savin-Williams & Ream, 2003 Cross-sectional; 681 sexual minority male youth; on-line convenience sample Gay-related stressors and identity variables (victimization, disclosure, gender expression) Self-esteem Suicide attempts Yes