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Elevated fibrillar collagen in ERK2 cKO primary astroglial cultures. Primary astroglial cultures derived from cKO or control littermate forebrains were labeled with mAb F1C3, recognizing an epitope shared on fibrillar collagens I/III. Scattered immunopositive cells were found in wild-type (WT) cultures (left panel). In contrast, virtually all cells from ERK2 cKO mice were F1C3 positive. Scale bar = 50 μm.
