Table 2.
Expression Profiling of ERK2 cKO Frontal Cerebral Cortex: Top 10 Up-Regulated Genes
| ID | Gene_assignment | Gene symbol | RefSeq | P value (ERK2-CKO vs WT) | Fold change (ERK2-cKO vs WT) |
|---|---|---|---|---|---|
| 10395534 | XM_001472023 // 100039062 // predicted gene, 100039062 // 12 B3 12 // 100039062 | 100039062 | XM_001472023 | 0.00125458 | 2.88604 |
| 10569344 | NM_001122737 // Igf2 // insulin-like growth factor 2 // 7 F5 7 69.09 cM // 16002 | Igf2 | NM_001122737 | 0.0423139 | 2.65605 |
| 10541318 | NM_144512 // Slc6a13 // solute carrier family 6 (neurotransmitter transporter, G | Slc6a13 | NM_144512 | 0.00355848 | 2.05448 |
| 10506110 | NM_001081202 // L1td1 // LINE-1 type transposase domain containing 1 // 4 C6 // | L1td1 | NM_001081202 | 0.0258555 | 1.99487 |
| 10483326 | NM_018852 // Scn9a // sodium channel, voltage-gated, type IX, α // 2 C1.3 2 | Scn9a | NM_018852 | 0.04023 | 1.94137 |
| 10552299 | NM_183166 // EG233164 // predicted gene, EG233164 // 7 B3 7 // 233164 /// ENSMUS | EG233164 | NM_183166 | 0.0393063 | 1.85383 |
| 10487605 | NM_177653 // F830045P16Rik // RIKEN cDNA F830045P16 gene // 2 F1 // 228592 /// E | F830045P16Rik | NM_177653 | 0.0418857 | 1.82114 |
| 10501433 | NM_177091 // Fndc7 // fibronectin type III domain containing 7 // 3 F3 // 320181 | Fndc7 | NM_177091 | 0.0315276 | 1.80687 |
| 10444674 | NM_023463 // Ly6g6c // lymphocyte antigen 6 complex, locus G6C // 17 B1 // 68468 | Ly6g6c | NM_023463 | 0.03225 | 1.80364 |
| 10559667 | NM_008350 // Il11 // interleukin 11 // 7 A1 7 2.0 cM // 16156 /// U03421 // Il11 | Il11 | NM_008350 | 0.0367704 | 1.80146 |
Differential mRNA expression between ERK2 cKO (n = 3) and littermate control (WT, n = 3) frontal cerebral cortex was assessed by microarray analysis using Affymetrix whole genome GeneChip Mouse Gene 1.0 ST arrays. WT, wild type.