Table 3.

Expression Profiling of ERK2 cKO Frontal Cerebral Cortex: Top 10 Down-Regulated Genes

Transcript ID	Gene_assignment	Gene symbol	RefSeq	P value (ERK2-cKO vs WT)	Fold change (ERK2-cKO vs WT)
10503196	NM_001081417 // Chd7 // chromodomain helicase DNA binding protein 7 // 4 A1 4 1	Chd7	NM_001081417	0.0108441	1.98634
10514466	NM_010591 // Jun // Jun oncogene // 4 C5-C7 4 44.6 cM // 16476 /// J04115 // Jun	Jun	NM_010591	0.0234714	−1.84637
10427035	NM_010444 // Nr4a1 // nuclear receptor subfamily 4, group A, member 1 // 15 F //	Nr4a1	NM_010444	0.0234266	−1.83148
10501277	NM_175470 // Gpr61 // G protein-coupled receptor 61 // 3 F2.3 // 229714 /// BC11	Gpr61	NM_175470	0.0062583	−1.82963
10395409	NM_008584 // Meox2 // mesenchyme homeobox 2 // 12 A3 12 20.0 cM // 17286 /// BC0	Meox2	NM_008584	0.0381391	−1.79783
10555722	NM_147104 // Olfr550 // olfactory receptor 550 // — // 259108 /// BC116960 //	Olfr550	NM_147104	0.0213001	−1.77826
10496359	NM_016885 // Emcn // endomucin // 3 G3 // 59308 /// BC003706 // Emcn // endomuci	Emcn	NM_016885	0.0368348	−1.73042
10418434	NM_008407 // Itih3 // inter-α trypsin inhibitor, heavy chain 3 // 14 A2-C1 /	Itih3	NM_008407	0.0193124	−1.73002
10391084	NM_010404 // Hap1 // huntingtin-associated protein 1 // 11 D 11 60.0 cM // 15114	Hap1	NM_010404	0.0221293	−1.7291
10422244	NM_175499 // Slitrk6 // SLIT and NTRK-like family, member 6 // 14 E3 // 239250 /	Slitrk6	NM_175499	0.0250078	−1.69499

Differential mRNA expression between ERK2 cKO (n = 3) and littermate control (wt, n = 3) frontal cerebral cortex was assessed by microarray analysis using Affymetrix whole genome GeneChip Mouse Gene 1.0 ST arrays. WT, wild type.