. 2009 Dec;175(6):2586–2599. doi: 10.2353/ajpath.2009.090130

Table 4.

Summary of Genotype/Phenotype Analyses

Mouse genotype	Cortical fibrils
C57BL/6 and Balb/C, wt background strains
ERK1^−/−(general KO)
NesCre;ERK2^wt/wt
NesCre;ERK2^wt/fl
NesCre;ERK2^fl/fl	+++
GFAPCre;ERK2^wt/wt
GFAPCre;ERK2^wt/fl
GFAPCre;ERK2^fl/fl	+
CamKIICre;ERK2^fl/fl
GFAPCre;TrkB^fl/fl

Cortical reticulin-positive fibrils were detected in brain-specific cKOs of ERK2 driven by Nestin:Cre and, to a lesser degree, by GFAP:Cre. No such fibrils were ever observed in wild-type background strains, in heterozygous cKOs driven by Nestin:Cre or GFAP:Cre, or in conditional ERK2 KOs driven by CamKIICre. No fibrils were observed in a brain-specific (GFAP:Cre) cKO of TrkB.