Figure 1.

Unilateral LPS injury results in bilateral ventricle dilation. Tissue sections from LPS-lesioned (n = 8) and vehicle control (n = 8) animals were stained using H&E and stereology software was used to measure whole brain sizes and ventricle ratios. H & E analysis revealed that compared with vehicle control (A–B), unilateral LPS lesioning resulted in bilateral enlargement of the ventricles (D–E). The average coronal brain size did not differ between groups (C). However, a significant increase in ventricle ratio of almost threefold was observed in LPS-lesioned animals at 8 weeks post-lesioning (F, * P < 0.01). Scale bar = 500 μm.