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. 2009 Dec;175(6):2309–2318. doi: 10.2353/ajpath.2009.081017

Figure 7.

Figure 7

TUNEL assay in GGTenu1 lung after treatment with L-NAME or D-NAME. GGTenu1 mice were treated with D-NAME (A) or L-NAME (B) and exposed to hyperoxia (H) as described in the Materials and Methods. C: Compared with the L-NAME pre-treated GGTenu1 mice in normoxia as control, there was 11-fold increase in lung TUNEL positive cells/500 nuclei in D-NAME treated GGTenu1 mice after exposure to hyperoxia (*P < 0.05), but only an eightfold increase L-NAME treated GGTenu1 mice exposed to hyperoxia. The 1.4-fold decrease in the number of lung TUNEL-positive cells/500 nuclei between the D-NAME and L-NAME treated mice exposed to hyperoxia was not statistically significant.