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. 2009 Dec;175(6):2309–2318. doi: 10.2353/ajpath.2009.081017

Figure 8.

Figure 8

TUNEL assay in wild-type (WT) lung after treatment with L-NAME or D-NAME. Wild-type mice were treated with D-NAME (A) or L-NAME (B) and exposed to hyperoxia (H) as in Figure 7. C: Compared with the L-NAME pretreated wild-type mice in normoxia as control (NL-NAME), there was a sixfold increase in TUNEL positive cells/500 nuclei in the D-NAME treated wild-type lung (HD-NAME) after exposure to hyperoxia, but only a threefold increase in the L-NAME treated wild-type lung (HL-NAME) after exposure to hyperoxia. The 2.2-fold decrease in the number of lung TUNEL positive cells/500 nuclei in L-NAME treated mice was significant compared with wild-type mice treated with D-NAME in hyperoxia. *P < 0.05.