Figure 4.

Similarities in the cerebellar cortex between ovine and human prion types regarding the deposition pattern of PrP^Sc. Synaptically located PrP^Sc deposits were characteristic for sporadic CJD type 1 (D; codon 129 methionine homozygote) and atypical/Nor98 sheep scrapie (C). In sporadic CJD type 2 (B; codon 129 methione/valine heterozygote) and classical sheep scrapie (A) more complex PrP^Sc aggregates were visible. Human PET blots: 12F10 1:5000 (B and D); ovine PET blots: mAb L42 (C) and P4 1:5000 (A); scale bar = 300 μm.