Table 1.

EAE Disease Assessment

Mouse strain*	EtOH		PE DHC		P value	n
	CDI	MDD	CDI	MDD
Wild type	10.1	0.5	19.8	1.0	0.001	28
TLR2−/−	7.6	0.4	8.3	0.4	0.306	15
IL-15−/−	9.4	0.5	24.5	1.2	0.001	10
IL-15Rα−/−	7.0	0.4	18.7	0.9	0.0077	12
Mouse strain†	Mean incidence		Mean maximum severity		Mean day of onset
	EtOH	PE DHC	EtOH	PE DHC	EtOH	PE DHC
Wild type	58.6	75	3.2	3.6	14.4	12.1
TLR2−/−	42.1	46.6	3.0	2.9	14.4	14.7
IL-15−/−	60	90	3.1	3.7	14.7	13.0
IL-15Rα−/−	66	100	2.7	2.9	15.1	13.8

^*The CDI was obtained by summing the daily average disease scores of each experimental group through day 20. A mean of these daily disease scores (MDD) was calculated based on the 20 days of observation. The MDD scores were compared using the Wilcoxon signed rank tests for two samples. n is the total number of mice studied in each experimental group. 

^†Mean incidence of disease is represented as a percentage and was calculated by dividing the number of mice within each group that developed clinical signs of EAE by the total number of mice in that group. Disease incidence frequencies were compared using χ² analysis. Mean maximum severity of EAE was calculated for mice that developed EAE by taking the highest score observed for each mouse in the 20-day observation period and averaging these values among mice in the same group. Statistical significance was determined using the Wilcoxon signed rank test. Mean day of onset of EAE was calculated for mice that developed EAE by using the first day of observance of signs of EAE as the value and averaging these values among mice in the same group. Statistical significance was determined using Student’s t-test.