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Polarized response of the outer BRB to ANP and VEGF. VEGF (10 ng/ml) and/or ANP (1 μmol/L) were given to the monolayer cell culture, and 120 minutes later, TEER values were obtained. Apical administration of VEGF significantly reduced TEER. ANP blocked VEGF-induced TEER reduction when given apically but not basolaterally; *P < 0.05.
