Table 4.
Top GO term leaves in phenotype correlation clusters
| Cluster | GOTERM | Description | Counts* | Category† | P Value |
|---|---|---|---|---|---|
| 1A | GO:0006897 | endocytosis | 33 | 163 | 2.46×10−4 |
| 1A | GO:0007015 | actin filament organization | 14 | 48 | 3.71×10−4 |
| 1A | GO:0015031 | protein transport | 95 | 635 | 4.89×10−4 |
| 1A | GO:0045670 | regulation of osteoclast differentiation | 7 | 16 | 7.83×10−4 |
| 1A | GO:0001525 | angiogenesis | 27 | 133 | 8.32×10−4 |
| 1A | GO:0045638 | negative regulation of myeloid cell differentiation | 8 | 21 | 9.91×10−4 |
| 1B | GO:0019886 | antigen processing, exogenous peptide antigen via MHC class II | 11 | 16 | 1.79×10−13 |
| 1B | GO:0030593 | neutrophil chemotaxis | 8 | 14 | 3.49×10−9 |
| 1B | GO:0042535 | positive regulation of tumor necrosis factor-α biosynthetic process | 5 | 8 | 2.03×10−6 |
| 1B | GO:0030048 | actin filament-based movement | 6 | 15 | 5.02×10−6 |
| 1B | GO:0045582 | positive regulation of T cell differentiation | 5 | 11 | 1.54×10−5 |
| 1B | GO:0006911 | phagocytosis, engulfment | 5 | 12 | 2.57×10−5 |
| 1B | GO:0051085 | chaperone cofactor-dependent protein folding | 5 | 12 | 2.57×10−5 |
| 1B | GO:0045059 | positive thymic T cell selection | 4 | 7 | 3.88×10−5 |
| 1B | GO:0019221 | cytokine and chemokine-mediated signaling pathway | 8 | 42 | 6.05×10−5 |
| 1B | GO:0030032 | lamellipodium biogenesis | 5 | 15 | 8.99×10−5 |
| 1B | GO:0050857 | positive regulation of antigen receptor-mediated signaling pathway | 3 | 4 | 1.42×10−4 |
| 1B | GO:0009968 | negative regulation of signal transduction | 11 | 89 | 1.68×10−4 |
| 1B | GO:0050766 | positive regulation of phagocytosis | 5 | 17 | 1.75×10−4 |
| 1B | GO:0050852 | T cell receptor signaling pathway | 5 | 18 | 2.36×10−4 |
| 1B | GO:0002573 | myeloid leukocyte differentiation | 7 | 45 | 6.45×10−4 |
| 1B | GO:0050798 | activated T cell proliferation | 4 | 13 | 6.75×10−4 |
| 1B | GO:0008360 | regulation of cell shape | 7 | 47 | 8.44×10−4 |
| 1B | GO:0007249 | I-κB kinase/NF-κB cascade | 9 | 77 | 9.84×10−4 |
| 2 | GO:0006695 | cholesterol biosynthetic process | 18 | 22 | 1.31×10−14 |
| 2 | GO:0006084 | acetyl-CoA metabolic process | 12 | 34 | 1.17×10−4 |
| 2 | GO:0001747 | eye development (sensu Mammalia) | 14 | 51 | 6.46×10−4 |
Gene Ontology (GO) term leaves were generated based on the induced GO graph resulting from all significant GO terms (P < 0.01).
*
Number of differentially expressed genes in a GO term category (false discovery rate <0.01);
†
Total number of genes in a GO term category.