Table 1.
Pathogen | % Unknown functiona | % Known functionb |
---|---|---|
Helicobacter pylori | 44.41 | 55.59 |
Pseudomonas aeruginosa | 64.67 | 35.33 |
Salmonella typhimurium | 46.53 | 53.47 |
Staphylococcus aureus | 42.17 | 57.83 |
Streptococcus pneumoniae | 36.57 | 63.43 |
Vibrio cholerae | 45.37 | 54.63 |
Yersinia pestis | 35.75 | 64.25 |
Allc | 52.59 | 47.41 |
The percentage of genes of unknown function comprises the functional classes defined by the Institute for Genomic Research (TIGR) within the Comprehensive Microbial Resource (CMR) database (http://www.tigr.org/tigr-scripts/CMR2/CMRHomePage.spl). Those classifications that are defined here as 'unknown' function are the hypothetical, conserved hypothetical, unclassified and unknown function.
The percentage of genes of known function comprises the remainder of the functional classes defined by TIGR. It should be noted that many of the genes in this class are categorized according to conserved motifs or predicted function (i.e. transporters, membrane proteins, regulatory functions and signal transduction) and might not be of actual known function. Therefore, the percentages listed are vast overestimates of the actual number of genes whose real roles are defined.
All represents the cumulative percentage of each functional class for all 87 of the completed genomes contained within the CMR.