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. 2008 Oct 8;15(6):1321–1329. doi: 10.1089/ten.tea.2008.0134

FIG. 6.

FIG. 6.

Nanotopography increases the adhesion of primary hepatocytes. Nanotopographic substrates increased the relative adhesion of hepatocytes to APS substrates. The nanotopographic 2DAHP-1G formulation exhibited a higher amount of relative adhesion than collagen substrates. Significance levels (***p < 0.001) determined by two-tailed Student's t-test. Similar trends observed in spreading were also observed in the adhesion of hepatocytes, with respect to the effect of nanotopography. Namely, the adhesion of hepatocytes cultured on flat APS substrates was significantly reduced compared to hepatocytes cultured on collagen (**p < 0.01 for 2DAHP-1G and ***p < 0.001 for 2DAHP-1T). Further, the adhesion of hepatocytes on nanotopographic APS substrates was observed to be comparable to collagen (p > 0.05 for both 2DAHP-1G and 2DAHP-1T).