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Statins and ezetimibe are associated with high levels of human plasma PCSK9 as a function of LDL-C reduction. Plasma PCSK9 levels of 139 hypercholesterolemic subjects were measured by ELISA as described. Hypercholesterolemic patients were being treated with one of the following: statins, ezetimibe, or a combination of both. The percent reduction in LDL-C was then plotted against PCSK9 levels (ng/ml). r and P were determined with GraphPad Prism software.
