Fig. 2.

Expression of ceramide metabolism-related genes in the right atrial appendage of lean (white bars, n = 11), overweight/obese (gray bars, n = 11) and overweight/obese type 2 diabetic (black bars, n = 15) patients. mRNA levels are expressed as a % of the lean group ± SEM. * significant difference versus lean subjects, † significant difference versus overweight/obese patients. SPT, serine palmitoyltransferase; SPHK, sphingosine kinase; al/n-Cdase, alkaline/neutral ceramidase; a-Cdase, acid ceramidase; n-Smase, neutral sphingomyelinase; a-Smase, acid sphingomyelinase.