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. Author manuscript; available in PMC: 2009 Dec 8.
Published in final edited form as: Nat Med. 2008 Sep 21;14(10):1097–1105. doi: 10.1038/nm.1868

Figure 6.

Figure 6

Effect of CypD deficiency on spatial learning and memory and on Aβ-induced LTP. (a,b) Radial water maze test in mice at 6 (a) and 12 months (b) of age. *P < 0.01 versus other groups of mice (n = 8-10 mice per group). R represents the retention test. (c) LTP in the indicated transgenic mice at 12-13 months of age. P < 0.05 comparing mAPP mice to other groups of mice. (d) LTP in the indicated mouse brain slices treated with vehicle or Aβ. P < 0.05 comparing Aβ-treated nonTg slices to Aβ-treated Ppif-/- slices and vehicle-treated nonTg or Ppif-/- slices. The horizontal bar indicates the period during which Aβ42 was added to the bath solution in this and in the experiments shown in the other graphs. (e) Effect of CSA (1 μM) on Aβ-induced LTP in nonTg hippocamal slices. P < 0.05 comparing Aβ-induced LTP to LTP in the slices treated with CSA plus Aβ, vehicle or CSA alone. P > 0.05 comparing CSA alone to vehicle-treated slices. (f) Effect of scavenging superoxide through perfusion with SOD (100 U ml-1) plus catalase (260 U ml-1) on Aβ-induced LTP in nonTg hippocampal slice. P < 0.05 comparing Aβ-treated slices to the slices treated with SOD + catalase + Aβ or with vehicle. P > 0.05 comparing vehicle-treated slices to the slices treated with SOD and catalase alone.