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Representative examples of responses of two muscular afferents to circumferential stretch before (pre) and 2 min after (post) application of an inflammatory soup (IS). Responses of fibers from wildtype (A) and P2X3−/− (B) mice are shown. Bottom: the circumferential stretch stimulus (5mN/sec force) was applied to the longitudinal edge of the colon preparation. The forces generated translate to intralumenal pressures between 0 and 45 mmHg.
