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. Author manuscript; available in PMC: 2011 Jan 1.
Published in final edited form as: Metabolism. 2009 Sep 18;59(1):100–106. doi: 10.1016/j.metabol.2009.07.012

Figure 2. Metabolic model.

Figure 2

One-compartment metabolic model used to analyze 13C turnover curves and determine the rate of TCA cycle. The model described the flow of 13C label from glucose C1 to glutamate C4 and C3. Loss of label occurs by dilution through exchange with unlabeled lactate and glutamine (Lac0 and Gln0 respectively). Parameters VTCA, VX, VDIL and VEFF were left as free parameters in the fit. Other fluxes were assumed: VGLY = 0.5 × VTCA and VGLN = 0.41 × VTCA.