Figure 5. Effect of transporter inhibitors on the efflux of 4-nitrophenyl sulfate from the apical membrane of BeWo cells.
BeWo monolayers grown on 12-well plates were incubated with 1 μM 4-nitrophenol at 37°C for 2 hours, in the presence of MRP inhibitors (MK-571, indomethacin, and leukotriene C4) or BCRP inhibitors (fumitremorgin C and chrysin). At the end of 2 hours, the incubation medium was analyzed for 4-nitrophenyl sulfate. Data has been plotted as mean ± S.E.M. * indicates p < 0.05.