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. Author manuscript; available in PMC: 2010 Nov 12.
Published in final edited form as: J Med Chem. 2009 Nov 12;52(21):6716–6723. doi: 10.1021/jm901016k

Figure 2.

Figure 2

Characterization of compound 1. A. Michaelis-Menten kinetic measurements, Lineweaver-Burk plot for 1 with VHR. B. FlexX docking of 1 into the active site of VHR crystal structure (PDB code 1J4X). The color code of the MOLCAD surface represents the lipophilic potential (brown: most hydrophobic, blue: most hydrophilic).