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. Author manuscript; available in PMC: 2009 Dec 8.
Published in final edited form as: Angew Chem Int Ed Engl. 2008;47(45):8605–8610. doi: 10.1002/anie.200804228

Scheme 4.

Scheme 4

Synthesis of crystalline derivative 34. Reagents and conditions: (a) DEAD (10 equiv), Ph3P (10 equiv), pNO2C6H4CO2H (10 equiv), benzene, 60 °C, 2 h, 88 % based on 58 % conversion; (b) LiDBB, THF, −78 → −50 °C; (c) HF•py/THF, 25 °C, 4 h; (d) pBrC6H4NCO (10 equiv), py, 40 °C, 70 % for the three steps.