Table 1.
CA inhibition data against isoforms CA I, II and IX a
| Kib (nM) | |||
|---|---|---|---|
| Compound | hCA I | hCA II | hCA IX |
| AZA | 250 ± 12 | 12 ± 1 | 25 ± 1 |
| 8 | 214 ± 9 | 230 ± 10 | 41 ± 2 |
| GNP-8 | 581 ± 18 (128) | 451 ± 21 (116) | 32 ± 2 (2.4) |
| 9 | >50,000 | >50,000 | >50,000 |
| GNP-9 | 28,550 | 30,400 | 31,050 |
| Au | 32,000 | 31,600 | 29,560 |
a
Reproduced with permission from [34] © 2003, American Chemical Society.
b
Inhibition constants (Ki) are obtained by nonlinear least-squares methods after being incubated with compound 15min.Data in parentheses show the inhibition constants when enzyme and inhibitor were incubated for 2 h.