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. 2009 Nov 20;10(10):4375–4417. doi: 10.3390/ijms10104375

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© 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.

This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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Figure 2. — Chemoattractive bioactivity of ECM degradation products. During the ECM remodeling process (due to activity of macrophages, SMC), degradation products are released into the blood stream these recruit multipotent progenitor cells (MPCs) from bone marrow by chemoattractant activity of the peptides and degradation products. The circulating progenitor cells (CPCs) then migrate to the site of implantation and aid in the endothelisation process.