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Adenovirus mediated transfection of multiple myeloma Delta47 and U266 cells with the DLC1 cDNA resulted in restored expression of the gene (A) and abundance of DLC1 mRNA (B), while transfection with control LacZ vector had no effect. Only transiently DLC1-positive Delta47 and U266 cells exhibited reduced ability to migrate (C) and decreased invasive capability (D) as measured by transendothelial migration and invasion essay.
