Figure 2 Means ± 2 SDs of metabolite ratios with between-group differences in change from baseline to week 24.

(A and B) Slight increases in N-acetylaspartate (NAA)/creatine (Cr) in the basal ganglia and in the centrum semiovale of the placebo group compared with the selegiline transdermal system (STS) groups (p = 0.023 and p = 0.072, respectively). Change in the absolute concentration of NAA was not significant. (C) Combined STS groups had higher levels of choline (Cho)/Cr in the midfrontal cortex (p = 0.002) compared with the placebo group after adjusting for baseline levels of the metabolite. A smaller difference in Cho (p = 0.046) was present when the absolute concentration of Cho was analyzed.