Table 3.

Empirical fit of mixtures of exponential probability density functions to the distributions of apparent shut times from human muscle acetylcholine nicotinic receptors activated by choline or TMA

Agonist (mm)	V (mV)	τ1 (ms)	Area 1 (%)	τ2 (ms)	Area 2 (%)	n
Choline
0.05	−80	0.016	26	1200	74	1
0.1	−80	0.013 ± 0.0005	42 ± 0.4	170 ± 30	58 ± 0.5	2
0.2	−80	0.011 ± 0.0002	49 ± 1	120 ± 70	51 ± 1	2
0.5	−80	0.012 ± 0.0003	50 ± 8	130 ± 80	50 ± 8	2
1	−80	0.012 ± 0.001	63 ± 2	98 ± 60	37 ± 2	2
2	−80	0.010 ± 0.001	73 ± 2	52 ± 30	27 ± 2	2
5	−80	0.011	75	51	25	1
10	−80	0.016 ± 0.002	65 ± 20	52 ± 20	31 ± 10	2
20	−80	0.08	4	50	96	1
50	−80	0.056	43	39	57	1
5	+80	0.018	43	3.1	57	1
10	+80	0.027	24	7.4	76	1
20	+80	0.024	17	11	83	1
50	+80	0.032 ± 0.01	22 ± 9	72 ± 6	70 ± 10	2
TMA
0.1	−80	0.012 ± 0.0004	57 ± 3	59 ± 40	43 ± 3	3
1	−80	0.014 ± 0.003	72 ± 3	8.9 ± 0.9	28 ± 3	2
3	−80	0.011 ± 0.00005	81 ± 1	2.41 ± 0.01	19 ± 1	2
10	−80	0.013 ± 0.0007	83 ± 3	1.4 ± 0.3	17 ± 3	3
30	−80	0.014 ± 0.0008	92 ± 1	1.2 ± 0.2	9 ± 1	2
100	−80			0.98 ± 0.1	100	3
0.3	+80	0.036	24	18	76	1
1	+80	0.030	54	17	46	1
3	+80	0.032	31	5.4	69	1
10	+80	0.024	35	2.1	66	1
30	+80	0.021	47	1.6	53	1
100	+80	0.028 ± 0.002	32 ± 2	1.5 ± 0.2	62 ± 2	2

n, number of patches. Time constants and areas are expressed as mean ±s.d.m.